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Our technology is featured in various prestigious scientific journals. To read more about our technology, please check out our featured publications below. You can also browse our Knowledge Base for detailed information on SERS, Raman Scattering etc. If you have any questions, feel free contact us using our contact form or give us a call.

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Advanced Optical Materials
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Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy

Application: Fabrication of SERS substrates

Citation: M. S. Schmidt, J. Hübner, and A. Boisen, Adv. Mater. 2012, 24, OP11-OP18

Summary: The paper presents a simple method for producing flexible, free-standing noble metal nanopillar structures for SERS applications. The nanopillars are fabricated from silicon and the resulting SERS substrates exhibit a remarkably large enhancement of the Raman signal due to analyte trapping.

Acs Nano
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Surface-Enhanced Raman Spectroscopy Based Quantitative Bioassay on Aptamer-Functionalized Nanopillars Using Large-Area Raman Mapping

Application: Detection of TAMRA-labeled vasopressin molecules

Citation: J. Yang, M. Palla, F. G. Bosco, T. Rindzevicius, T. S. Alstrøm, M. S. Schmidt, A. Boisen, J. Ju, and Q. Lin, ACS NANO 2013, 7, 5350-5359.

Summary: In this study, TAMRA-labeled vasopressin molecules in the picomolar regime (1 pM to 1 nM) are specifically captured by aptamers on the gold nanopillar SERS substrate and monitored by using an automated SERS signal mapping technique.

Transducers2013 2
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A Microfluidic surface enhanced Raman spectroscopy biosensor using aptamer functionalized nanopillars

Application: Detection of vasopressin molecules employing a microfluidics SERS set-up

Citation: J. Yang, M. Palla, F. G. Bosco, M. S. Schmidt, T. Rindzevicius, A. Boisen, J. Ju, Q. Lin, IEEE Transducers, 2013, 1799-1802

Summary: In a temperature controlled microchamber, aptamers immobilized on the gold nanopillar surface specifically recognize target molecules. The device demonstrates quatitative detection of vasopressin in the picomolar regime.

Advanced Optical Materials
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Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates

Application: SERS detection of folic acid (cancer related applications)

Citation: J. J. Castillo, T. Rindzevicius, K. Wu, M. S. Schmidt, K. A. Janik, A. Boisen, W. Svendsen, N. Rozlosnik, J. Castillo-León, J. Nanopart. Res., 2014, 16, 1-8

Summary: The paper presents a synthesis procedure to form diphenylalanine (PNT) and folic acid (FA) conjugates. The PNT-FA conjugate is a promising candidate for applications in the detection and diagnosis of cancer or tropical diseases such as leishmaniasis and as a carrier nanosystem delivering drugs to malignant tumors that overexpress folate receptors.

Analytica Chimica Acta
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Non-labeling multiplex surface enhanced Raman scattering (SERS) detection of volatile organic compounds (VOCs)

Application: SERS detection of VOCs

Citation: C. L. Wonga, U.S. Dinisha, M. S. Schmidt, M. Olivoa, Anal. Chim. Acta, 2014, 844, 54-60

Summary: In this paper, we report multiplex SERS based VOCs detection with a leaning nano-pillar substrate. The VOCs analyte molecules adsorbed at the tips of the nano-pillars produced SERS signal due to the field enhancement occurring at the localized surface plasmon hot spots between adjacent leaning nano-pillars.

The Journal of Physical Chemistry C
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Wafer-Scale Leaning Silver Nanopillars for Molecular Detection at Ultra-Low Concentrations

Application: Wafer-scale SERS substrates

Citation: K. Wu, T. Rindzevicius, M. S. Schmidt, K. Bo Mogensen, A. Hakonen, and A. Boisen, J. Phys. Chem. C, 2015, 119, 2053-2062

Summary: Wafer-scale surface-enhanced Raman scattering (SERS) substrates fabricated using maskless lithography are important for scalable production targets. Large-area, leaning silver-capped silicon nanopillar (Ag NP) structures suitable for SERS molecular detection at extremely low analyte concentrations are presented.

Osa Oe
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Plasmon resonances of Ag capped Si nanopillars fabricated using mask-less lithography

Application: Optical properties of Ag-capped Si nanopillar structures

Citation: K. Wu, T. Rindzevicius, M. S. Schmidt, K. Bo Mogensen, S. Xiao, and A. Boisen, OPTICS EXPRESS, 2015, 23, 12965-12978

Summary: Localized surface plasmon resonances (LSPR) and plasmon coupling in Ag capped Si nanopillar structures are studied using 3D FEM simulations and dark-field scattering microscopy.

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Silver-capped silicon nanopillar platforms for adsorption studies of folic acid using surface enhanced Raman spectroscopy and density functional theory

Application: SERS and DFT of folic acid molecule

Citation: J. J. Castillo, T. Rindzevicius, K. Wu, C. E. Rozo, M. S. Schmidt, and A. Boisen, J. Raman Spectrosc., 2015, 46, 1087-1094

Summary: The paper presents a study of the adsorption of FA on silver-capped silicon nanopillar substrates employing surface enhanced Raman scattering spectroscopy and density functional theory calculations.

Sensing And Bio Sensing Research
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Towards quantitative SERS detection of hydrogen cyanide at ppb level for human breath analysis

Application: SERS-based detection of HCN

Citation: R. K. Lauridsen, T. Rindzevicius, S. Molin, H. K. Johansen, R. W. Berg, T. S. Alstrøm, K. Almdal, F. Larsen, M. S. Schmidt, and A. Boisen, Sensing and Bio-Sensing Research, 2015, 5, 84-89

Summary: Lung infections with Pseudomonas aeruginosa (PA) is the most common cause of morbidity and mortality in cystic fibrosis (CF) patients. Hydrogen cyanide (HCN) at ppb level has been reported to be a PA biomarker. For early PA detection in CF children not yet chronically lung infected a non-invasive SERS-based breath nanosensor is being developed.

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Mathematical Model for Biomolecular Quantification Using Large-Area Surface-Enhanced Raman Spectroscopy Mapping

Application: SERS signal mapping: biomolecular quantification

Citation: M. Palla, F. G. Bosco, J. Yang, T. Rindzevicius, T. S. Alstrøm, M. S. Schmidt, Q. Lin, J. Ju, A. Boisen, RSC Advances, 2015, 5, 85845-85853

Summary: A mathematical model to predict experimental SERS signal intensity distributions of target molecules on receptor functionalized nanopillar substrates for biomolecular quantification is presented. Our general theoretical framework agrees with the experimental data particularly well in the picomolar concentration regimes.

Nanoscale Cover2015
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Detection of nerve gases using surface-enhanced Raman scattering substrates with high droplet adhesion

Application: SERS-based detection of two nerve gases, VX and Tabun

Citation: A. Hakonen, T. Rindzevicius, M. S. Schmidt, P. O. Andersson, L. Juhlin, M. Svedendahl, A. Boisen, and M. Käll, Nanoscale, 2016, 8, 1305-1308

Summary:Here we demonstrate that surface-enhanced Raman scattering (SERS) can be used for sensitive detection of femtomol quantities of two nerve gases, VX and Tabun, using a handheld Raman device and SERS substrates consisting of flexible gold-covered Si nanopillars.